Beilstein J. Org. Chem.2017,13, 451–494, doi:10.3762/bjoc.13.48
. Fluoroorganiccompounds play a significant role as very effective therapeutics, and for this reason, Prakash, Olah et al. synthesized in 2010 trifluoromethyl-substituted arylpropanoic acids 12, 1-indanones 13 and dihydrocoumarins 14 (Scheme 5) [17]. These products have been obtained by utilizing arenes/phenols
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Graphical Abstract
Figure 1:
Biologically active 1-indanones and their structural analogues.
Beilstein J. Org. Chem.2011,7, 1421–1435, doi:10.3762/bjoc.7.166
-ketoenolates as key reaction intermediates, was obtained. Based on the experimental findings, a general mechanistic sketch and a steric model of induction are proposed.
Keywords: Asymmetric catalysis; fluorination; fluoroorganiccompounds; TADDOL; titanium; Introduction
Fluoroorganiccompounds have peculiar
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Graphical Abstract
Figure 1:
Fluorinated substances of biomedical relevance.